Imaging and Modelling of Cellular Life Symposium
The imaging and modelling of cellular life symposium aims to highlight research that uses high-end imaging, quantitative image analysis and mathematical modelling methods. Talks will be given by researchers that use multi-disciplinary approaches to answer their research questions.
1-5pm, Friday 14th September 2018
Auditorium, Peter Doherty Institute, 792 Elizabeth Street, Melbourne, 3010
Free and open to all. Please register here
Program: The plenary address will be given by Prof Mark Ellisman from the University of California, San Diego.
1:00 – 1:25
CryoEM: Imaging the conformational dynamics of the malaria parasite proteasome
1:25 – 1:50
Quantitative analyses of the actin cytoskeleton in plant cells
1:50 – 2:15
Multiscale imaging of musculoskeletal mechanobiology
2:25 – 2:40
The cardiomyocyte under the mathematical microscope
2:40 – 3:10
3:10 – 3:35
A spatio-temporal model and inference tools for longitudinal count data on multicolour cell growth
3:35 – 4:00
Mapping the visceral connectome
4:00 – 4:45
Revealing Secrets Hiding in Plain Sight: Recent Advances in Multi-scale Multi-modal Imaging
Abstract: Biologists strive to obtain a more complete understanding of how molecular, cellular and tissue physiology plays out across a daunting range of spatial and temporal scales. Current imaging methods leave significant gaps unfilled or poorly mapped, limiting the comprehensiveness of our knowledge regarding the complexities of structure and function within cell and tissue systems. Multiple methods are now being combined to bridge critical gaps. Examples taken from ongoing projects will highlight development and application of new contrasting methods, imaging tools and data analysis strategies, which when used in combination, allow us to disclose otherwise complex or hidden relationships between cellular, subcellular and molecular constituents of cells. These advances are now being applied to study the brain and to analyze its cells and synapses during learning, with aging or during development of degenerative brain disorders, like Alzheimer’s or Parkinson’s. Recent work analyzing the functional organization of chromatin of intact cell nuclei as well as on actin-associated structures of dendritic spines of neurons will also be described. Opportunities to further advance multi-scale multi-modal imaging strategies to hasten understanding of complex biological systems will be discussed.